The effects of the ellagic acid on the in vitro and in vivo acetylation of 2-aminofluorene were investigated in male Sprague-Dawley rats. For in vitro examination, cytosols with or without ellagic acid co-treatment showed different percentage of 2-aminofluorene acetylation. For in vivo examination, pre-treatment of male rats with ellagic acid (10 mg/kg) 24h prior to the administration of 2-aminofluorene (50 mg/kg) resulted in a 26% and 29%, respectively, decrease in the urinary and fecal recovery of N-acetyl-2-aminofluorene, and a 37% decrease in the metabolic clearance of 2-aminofluorene to N-acetyl-2-aminofluorene. This is the first demonstration that ellagic acid decrease the N-acetylation of carcinogens in vitro and in vivo.
關聯:
Toxicological and environmental chemistry 71(3-4 )319 ~329
