Effects of the Ellagic acid on the N-Acetyltransferase activity and Acetylation of 2-aminofluorene in the rat.

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Title:	Effects of the Ellagic acid on the N-Acetyltransferase activity and Acetylation of 2-aminofluorene in the rat.
Authors:	(Ho, C.C.);(Tsai, H.Y.);(Lai, Y.S.);鍾景光(Chung, Jing-Gung)
Contributors:	醫學院生物科技學系;中國附醫醫學研究部 Ellagic acid;acetylation;2-aminofluorene;carcinogenesis;anti-carcinogen
Date:	1999-04
Issue Date:	2009-08-26 16:07:26 (UTC+8)
Abstract:	The effects of the ellagic acid on the in vitro and in vivo acetylation of 2-aminofluorene were investigated in male Sprague-Dawley rats. For in vitro examination, cytosols with or without ellagic acid co-treatment showed different percentage of 2-aminofluorene acetylation. For in vivo examination, pre-treatment of male rats with ellagic acid (10 mg/kg) 24h prior to the administration of 2-aminofluorene (50 mg/kg) resulted in a 26% and 29%, respectively, decrease in the urinary and fecal recovery of N-acetyl-2-aminofluorene, and a 37% decrease in the metabolic clearance of 2-aminofluorene to N-acetyl-2-aminofluorene. This is the first demonstration that ellagic acid decrease the N-acetylation of carcinogens in vitro and in vivo.
Relation:	Toxicological and environmental chemistry 71(3-4 )319 ~329
Appears in Collections:	[Department of Biological Science and Technology] Journal articles

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