Effects of the Ellagic acid on the N-Acetyltransferase activity and Acetylation of 2-aminofluorene in the rat.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 生命科學院 > 生物科技學系暨碩士班 > 期刊論文 > Item 310903500/7008

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/7008

题名:	Effects of the Ellagic acid on the N-Acetyltransferase activity and Acetylation of 2-aminofluorene in the rat.
作者:	(Ho, C.C.);(Tsai, H.Y.);(Lai, Y.S.);鍾景光(Chung, Jing-Gung)
贡献者:	醫學院生物科技學系;中國附醫醫學研究部 Ellagic acid;acetylation;2-aminofluorene;carcinogenesis;anti-carcinogen
日期:	1999-04
上传时间:	2009-08-26 16:07:26 (UTC+8)
摘要:	The effects of the ellagic acid on the in vitro and in vivo acetylation of 2-aminofluorene were investigated in male Sprague-Dawley rats. For in vitro examination, cytosols with or without ellagic acid co-treatment showed different percentage of 2-aminofluorene acetylation. For in vivo examination, pre-treatment of male rats with ellagic acid (10 mg/kg) 24h prior to the administration of 2-aminofluorene (50 mg/kg) resulted in a 26% and 29%, respectively, decrease in the urinary and fecal recovery of N-acetyl-2-aminofluorene, and a 37% decrease in the metabolic clearance of 2-aminofluorene to N-acetyl-2-aminofluorene. This is the first demonstration that ellagic acid decrease the N-acetylation of carcinogens in vitro and in vivo.
關聯:	Toxicological and environmental chemistry 71(3-4 )319 ~329
显示于类别:	[生物科技學系暨碩士班] 期刊論文

文件中的档案:

档案	大小	格式	浏览次数
	0Kb	Unknown	368	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章