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| 題名: | Comparison of cyfra 21-1 and squamous cell carcinoma antigen in detecting nasopharyngeal carcinoma |
| 作者: | Lee, JK;Hsieh, JF;Tsai, SC;Ho, YJ;Sun, SS;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 400, Taiwan;Jen Ai Hosp, Dept Radiol, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung, Taiwan;Chi Mei Fdn Hosp, Dept Nucl Med, Tainan, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Changhua, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 14:36:39 (UTC+8) |
| 出版者: | ANNALS PUBL CO |
| 摘要: | To evaluate whether or not (-)-menthol affects arylamine N-acetyltransferase (NAT) activity, we selected human liver tumor cell tine (J 5) for examination. By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined. (-)Menthol displayed a dose-dependent inhibition to cytosolic NAT activity. Time-course experiments showed that NAT activity measured from intact human liver tumor cells was inhibited by (-)-menthol for up to 24 hrs. But in human liver tumor intact cells, the low doses (0.0032 and 0.032 mM) of (-)-menthol promoted the NAT activity and the high doses (3.2 and 32 mM) of (-)-menthol inhibited NAT activity and the 0.32 mM (-)-menthol did not show any significant differences between control and (-)-menthol treated groups. Using standard steady-state kinetic analysis, it was demonstrated that (-)-menthol was a possible uncompetitive inhibitor (decrease Km and Vmax) to NAT activity in cytosols. This report is the first demonstration which showed (-)-menthol affect on human liver tumor cells NAT activity. |
| 關聯: | ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 110(8):775-778 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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