Comparison of cyfra 21-1 and squamous cell carcinoma antigen in detecting nasopharyngeal carcinoma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29514

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题名:	Comparison of cyfra 21-1 and squamous cell carcinoma antigen in detecting nasopharyngeal carcinoma
作者:	Lee, JK;Hsieh, JF;Tsai, SC;Ho, YJ;Sun, SS;Kao, CH
贡献者:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 400, Taiwan;Jen Ai Hosp, Dept Radiol, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung, Taiwan;Chi Mei Fdn Hosp, Dept Nucl Med, Tainan, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Changhua, Taiwan
日期:	2001
上传时间:	2010-09-24 14:36:39 (UTC+8)
出版者:	ANNALS PUBL CO
摘要:	To evaluate whether or not (-)-menthol affects arylamine N-acetyltransferase (NAT) activity, we selected human liver tumor cell tine (J 5) for examination. By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined. (-)Menthol displayed a dose-dependent inhibition to cytosolic NAT activity. Time-course experiments showed that NAT activity measured from intact human liver tumor cells was inhibited by (-)-menthol for up to 24 hrs. But in human liver tumor intact cells, the low doses (0.0032 and 0.032 mM) of (-)-menthol promoted the NAT activity and the high doses (3.2 and 32 mM) of (-)-menthol inhibited NAT activity and the 0.32 mM (-)-menthol did not show any significant differences between control and (-)-menthol treated groups. Using standard steady-state kinetic analysis, it was demonstrated that (-)-menthol was a possible uncompetitive inhibitor (decrease Km and Vmax) to NAT activity in cytosols. This report is the first demonstration which showed (-)-menthol affect on human liver tumor cells NAT activity.
關聯:	ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 110(8):775-778
显示于类别:	[台中附設醫院] 期刊論文

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