Inhibition of Phospholipase Cγ1 and Cancer Cell Proliferation by Triterpene Esters from Uncaria rhynchophylla

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题名:	Inhibition of Phospholipase Cγ1 and Cancer Cell Proliferation by Triterpene Esters from Uncaria rhynchophylla
作者:	(Ji Suk Lee);(Jinwoong Kim);(Bo Yeon Kim);(Hyun Sun Lee);(Jong Seog Ahn);張永勳(Yuan Shiun Chang)
贡献者:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
日期:	2000
上传时间:	2009-08-26 16:22:30 (UTC+8)
摘要:	Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cγ1 (PLCγ1) inhibitors (1−6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCγ1 in vitro with IC50 values of 9.5−44.6 μM and inhibited the proliferation of human cancer cells with IC50 values of 0.5−6.5 μg/mL.
關聯:	Journal of Nature Products 63(6)753~756
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

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