Inhibition of Phospholipase Cγ1 and Cancer Cell Proliferation by Triterpene Esters from Uncaria rhynchophylla

CMUR > College of Pharmacy > Graduate Institute of Chinese Pharmaceutical Science > Journal articles > Item 310903500/7397

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/7397

Title:	Inhibition of Phospholipase Cγ1 and Cancer Cell Proliferation by Triterpene Esters from Uncaria rhynchophylla
Authors:	(Ji Suk Lee);(Jinwoong Kim);(Bo Yeon Kim);(Hyun Sun Lee);(Jong Seog Ahn);張永勳(Yuan Shiun Chang)
Contributors:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
Date:	2000
Issue Date:	2009-08-26 16:22:30 (UTC+8)
Abstract:	Investigation of the hooks of Uncaria rhynchophylla resulted in isolation of six phospholipase Cγ1 (PLCγ1) inhibitors (1−6). The structures of these compounds were elucidated as pentacyclic triterpene esters by spectroscopic and chemical analysis. Three of them, namely uncarinic acids C (1), D (2), and E (3), are newly reported as natural products. All the compounds showed dose-dependent inhibitory activities against PLCγ1 in vitro with IC50 values of 9.5−44.6 μM and inhibited the proliferation of human cancer cells with IC50 values of 0.5−6.5 μg/mL.
Relation:	Journal of Nature Products 63(6)753~756
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	350	View/Open