Analgesic and Anti-inflammatory Activities of Methanol Extract from Desmodium triflorum DC in Mice

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题名:	Analgesic and Anti-inflammatory Activities of Methanol Extract from Desmodium triflorum DC in Mice
作者:	(Shang-Chih Lai);彭文煌(Wen-Huang Peng);黃順爵(Shun Chieh Huang);何玉鈴;黃太鴻(Huang,Tai-Hung);(Zhen-Rung Lai);張永勳(Yuan Shiun Chang)*
贡献者:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
关键词:	Desmodium triflorum;Anti-Inflammation;Analgesia;Malondialdehyde;Nitric Oxide;Tumor Necrosis Factor-α;Vitexin
日期:	2009
上传时间:	2009-08-26 16:21:18 (UTC+8)
摘要:	In this study, we evaluated the analgesic effect of methanol extract from Desmodium triflorum DC (MDT) by using animal models of acetic acid-induced writhing response and formalin test. The anti-inflammatory effect of MDT was investigated by λ-carrageenan-induced paw edema in mice. In order to study the anti-inflammatory mechanism of MDT, we detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver, the levels of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), malondialdehyde (MDA) and nitric oxide (NO) in the edema paw tissue. In the analgesic test, MDT (0.5 and 1.0 g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, MDT (0.5 and 1.0 g/kg) decreased the paw edema at the 3rd, 4th, 5th and 6th hour after λ-carrageenan administration. On the other hand, MDT increased the activities of SOD and GRd in liver tissues and decreased the MDA level in the edema paw at the 3rd hour after λ-carrageenan-induced inflammation. MDT also affected the levels of interleukin-1β, tumor necrosis factor-α, NO and MDA which were induced by λ-carrageenan. The results suggested that MDT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of MDT might be related to the decreases in the level of MDA in the edema paw via increasing the activities of SOD and GRd in the liver, and the NO level via regulating the IL-1β production and the level of TNF-α in the inflamed tissues.
關聯:	AMERICAN JOURNAL OF CHINESE MEDICINE 37(3)573 ~588
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

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