Analgesic and Anti-inflammatory Activities of Methanol Extract from Desmodium triflorum DC in Mice

CMUR > College of Pharmacy > Graduate Institute of Chinese Pharmaceutical Science > Journal articles > Item 310903500/7360

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/7360

Title:	Analgesic and Anti-inflammatory Activities of Methanol Extract from Desmodium triflorum DC in Mice
Authors:	(Shang-Chih Lai);彭文煌(Wen-Huang Peng);黃順爵(Shun Chieh Huang);何玉鈴;黃太鴻(Huang,Tai-Hung);(Zhen-Rung Lai);張永勳(Yuan Shiun Chang)*
Contributors:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
Keywords:	Desmodium triflorum;Anti-Inflammation;Analgesia;Malondialdehyde;Nitric Oxide;Tumor Necrosis Factor-α;Vitexin
Date:	2009
Issue Date:	2009-08-26 16:21:18 (UTC+8)
Abstract:	In this study, we evaluated the analgesic effect of methanol extract from Desmodium triflorum DC (MDT) by using animal models of acetic acid-induced writhing response and formalin test. The anti-inflammatory effect of MDT was investigated by λ-carrageenan-induced paw edema in mice. In order to study the anti-inflammatory mechanism of MDT, we detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver, the levels of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), malondialdehyde (MDA) and nitric oxide (NO) in the edema paw tissue. In the analgesic test, MDT (0.5 and 1.0 g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, MDT (0.5 and 1.0 g/kg) decreased the paw edema at the 3rd, 4th, 5th and 6th hour after λ-carrageenan administration. On the other hand, MDT increased the activities of SOD and GRd in liver tissues and decreased the MDA level in the edema paw at the 3rd hour after λ-carrageenan-induced inflammation. MDT also affected the levels of interleukin-1β, tumor necrosis factor-α, NO and MDA which were induced by λ-carrageenan. The results suggested that MDT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of MDT might be related to the decreases in the level of MDA in the edema paw via increasing the activities of SOD and GRd in the liver, and the NO level via regulating the IL-1β production and the level of TNF-α in the inflamed tissues.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE 37(3)573 ~588
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	628	View/Open

Loading...