Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extracts on Testosterone Release from Rat Leydig Cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 中國藥學研究所(已停用) > 期刊論文 > Item 310903500/7333

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/7333

题名:	Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extracts on Testosterone Release from Rat Leydig Cells
作者:	(Shih-Min Hsia);(Yi-Wen Tseng);(Shyi-Wu Wang);郭悅雄;(Din-Wen Huang);(Paulus S. Wang);(Wenchang Chiang)
贡献者:	藥學院中國藥學研究所;中國附醫院長室
关键词:	adlay hulls;testosterone;Leydig cell
日期:	2009
上传时间:	2009-08-26 16:20:20 (UTC+8)
摘要:	Adlay has been used as a traditional Chinese medicine for the treatment of many diseases. However, few studies have reported the effects of adlay seeds on the endocrine system. In the present study, the effects of methanol extracts of adlay hull (AHM) on testosterone synthesis were studied. Rat Leydig cells were incubated with different reagents including human chorionic gonadotropin, 8-bromo-adenosine-3,5-cyclic monophosphate, forskolin, A23187, progesterone and androstenedione in the presence or absence of AHM. The rat anterior pituitary (AP) gland was treated with gonadotropin-releasing hormone (GnRH) in vitro in the presence or absence of AHM, and the concentrations of luteinizing hormone (LH) in the media were measured. AHM decreased testosterone release via the inhibition of (1) the PKA and PKC signal transduction pathways, (2) 17-HSD enzyme activity in rat Leydig cells, and (3) in vitro GnRH-induced LH secretion.
關聯:	PHYTOTHERAPY RESEARCH 23( )687~695
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	588	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章