Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extracts on Testosterone Release from Rat Leydig Cells

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Title:	Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extracts on Testosterone Release from Rat Leydig Cells
Authors:	(Shih-Min Hsia);(Yi-Wen Tseng);(Shyi-Wu Wang);郭悅雄;(Din-Wen Huang);(Paulus S. Wang);(Wenchang Chiang)
Contributors:	藥學院中國藥學研究所;中國附醫院長室
Keywords:	adlay hulls;testosterone;Leydig cell
Date:	2009
Issue Date:	2009-08-26 16:20:20 (UTC+8)
Abstract:	Adlay has been used as a traditional Chinese medicine for the treatment of many diseases. However, few studies have reported the effects of adlay seeds on the endocrine system. In the present study, the effects of methanol extracts of adlay hull (AHM) on testosterone synthesis were studied. Rat Leydig cells were incubated with different reagents including human chorionic gonadotropin, 8-bromo-adenosine-3,5-cyclic monophosphate, forskolin, A23187, progesterone and androstenedione in the presence or absence of AHM. The rat anterior pituitary (AP) gland was treated with gonadotropin-releasing hormone (GnRH) in vitro in the presence or absence of AHM, and the concentrations of luteinizing hormone (LH) in the media were measured. AHM decreased testosterone release via the inhibition of (1) the PKA and PKC signal transduction pathways, (2) 17-HSD enzyme activity in rat Leydig cells, and (3) in vitro GnRH-induced LH secretion.
Relation:	PHYTOTHERAPY RESEARCH 23( )687~695
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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