New Molecular Insights into Cellular Survival and Stress Responses: Neuroprotective Role of Cellular Prion Protein (PrPC)

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 分子系統生物醫學研究所 > 期刊論文 > Item 310903500/6939

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題名:	New Molecular Insights into Cellular Survival and Stress Responses: Neuroprotective Role of Cellular Prion Protein (PrPC)
作者:	(Raymond Yen-Yu Lo);徐偉成;林欣榮(Shinn-Zong Lin);王孝榮(Hsiao-Jung Wang);(Shun-Sheng Chen);李鴻(Hung Li)*
貢獻者:	醫學院分子系統生物醫學研究所;中國附醫院長室
關鍵詞:	Prion;PrPc;Neuroprotection;Oxidative stress;Cell survival;TSE
日期:	2007-06
上傳時間:	2009-08-26 16:05:04 (UTC+8)
摘要:	Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt–Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.
關聯:	MOLECULAR NEUROBIOLOGY 35(3)236 ~244
顯示於類別:	[分子系統生物醫學研究所] 期刊論文

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