New Molecular Insights into Cellular Survival and Stress Responses: Neuroprotective Role of Cellular Prion Protein (PrPC)

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Title:	New Molecular Insights into Cellular Survival and Stress Responses: Neuroprotective Role of Cellular Prion Protein (PrPC)
Authors:	(Raymond Yen-Yu Lo);徐偉成;林欣榮(Shinn-Zong Lin);王孝榮(Hsiao-Jung Wang);(Shun-Sheng Chen);李鴻(Hung Li)*
Contributors:	醫學院分子系統生物醫學研究所;中國附醫院長室
Keywords:	Prion;PrPc;Neuroprotection;Oxidative stress;Cell survival;TSE
Date:	2007-06
Issue Date:	2009-08-26 16:05:04 (UTC+8)
Abstract:	Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt–Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.
Relation:	MOLECULAR NEUROBIOLOGY 35(3)236 ~244
Appears in Collections:	[Graduate Institute of Molecular System Biomedicine] Journal articles

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