| 摘要: | Background: It has been reported that restless legs syndrome (RLS) is more
prevalent in patients with chronic obstructive pulmonary disease (COPD) than in the
general population. RLS negatively impacts on sleep and health quality of COPD patients.
However, large-scaled, population-based and long-term study was lacking. Whether COPD
are in greater risk of RLS remain unknown.
Objectives: To identify the incidence of RLS among COPD patients and evaluate
risks of sociodemographic variables and comorbidities for COPD patients with and without
RLS using population-based data.
Methods: A retrospective cohort study by using Taiwan National Health Insurance
Research Database (NHIRD). The COPD cohort consisting of 77831 individuals aged ? 20
years with newly COPD diagnosis during 2000-2010. Same number of individuals without
COPD selected as the comparison cohort. The cohorts were frequency matched by sex, age
and index year. Both cohorts were followed up to the end of 2011 to estimate the incidence
and Hazard ratios (HRs) of developing RLS.
Results: Individuals who were diagnosed with COPD had a 2.12-fold higher
incidence of RLS than did those free of COPD (6.67 and 3.08 per 10,000 person-year, the
aHR was 2.12 (95% CI 1.78 – 2.52) after adjusting for age, sex, occupation, income and
comorbidities. In COPD cohort, the rate of RLS incidence in female was higher than in
male (6.80 and 6.56 per 10,000 person-year, respectively). The highest RLS incidence rate
was found among COPD patients of ? 65 years old, < 20,000 NTD, retired and
unemployed (8.31, 8.28, 14.2 per 10,000 person-years, respectively). Among patients with
at least one comorbidity, there was no significant difference between two cohorts for RLS
risk (aHR, 1.23 [95% CI 0.79 – 1.92]).
Conclusion: Patients with COPD are at an increased risk of developing RLS
regardless of gender, age and occupation. RLS risk should be particularly cautious among
COPD patients who are female, aging and with low socioeconomic status. Future research
is needed to better understand the underlying causal mechanism of COPD and increased
risk of RLS. |
