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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/59068


    Title: The risk of restless legs syndrome in patients with chronic obstructive pulmonary disease: A nationwide retrospective cohort study
    The risk of restless legs syndrome in patients with chronic obstructive pulmonary disease: A nationwide retrospective cohort study
    Authors: Thi Be Em Truong
    Contributors: 護理學系碩士班
    Keywords: Restless legs syndrome;Wiliss-Ekbom disease;Chronic obstructive pulmonary disease;Chronic obstructive airway disease;Chronic obstructive lung disease
    Date: 2019-07-23
    Issue Date: 2019-11-11 09:44:15 (UTC+8)
    Publisher: 中國醫藥大學
    Abstract: Background: It has been reported that restless legs syndrome (RLS) is more
    prevalent in patients with chronic obstructive pulmonary disease (COPD) than in the
    general population. RLS negatively impacts on sleep and health quality of COPD patients.
    However, large-scaled, population-based and long-term study was lacking. Whether COPD
    are in greater risk of RLS remain unknown.
    Objectives: To identify the incidence of RLS among COPD patients and evaluate
    risks of sociodemographic variables and comorbidities for COPD patients with and without
    RLS using population-based data.
    Methods: A retrospective cohort study by using Taiwan National Health Insurance
    Research Database (NHIRD). The COPD cohort consisting of 77831 individuals aged ? 20
    years with newly COPD diagnosis during 2000-2010. Same number of individuals without
    COPD selected as the comparison cohort. The cohorts were frequency matched by sex, age
    and index year. Both cohorts were followed up to the end of 2011 to estimate the incidence
    and Hazard ratios (HRs) of developing RLS.
    Results: Individuals who were diagnosed with COPD had a 2.12-fold higher
    incidence of RLS than did those free of COPD (6.67 and 3.08 per 10,000 person-year, the
    aHR was 2.12 (95% CI 1.78 – 2.52) after adjusting for age, sex, occupation, income and
    comorbidities. In COPD cohort, the rate of RLS incidence in female was higher than in
    male (6.80 and 6.56 per 10,000 person-year, respectively). The highest RLS incidence rate
    was found among COPD patients of ? 65 years old, < 20,000 NTD, retired and
    unemployed (8.31, 8.28, 14.2 per 10,000 person-years, respectively). Among patients with
    at least one comorbidity, there was no significant difference between two cohorts for RLS
    risk (aHR, 1.23 [95% CI 0.79 – 1.92]).
    Conclusion: Patients with COPD are at an increased risk of developing RLS
    regardless of gender, age and occupation. RLS risk should be particularly cautious among
    COPD patients who are female, aging and with low socioeconomic status. Future research
    is needed to better understand the underlying causal mechanism of COPD and increased
    risk of RLS.
    Appears in Collections:[School and Institute of Nursing] Theses & dissertations

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