本研究開發出一套心率變異分析系統，可藉由心率變異信號的時域與頻域分析結果，來分析交感神經與副交感神經調變的情形，並進一步探討自律神經功能與中醫陰陽體質的相關性。我們以中國醫藥學院附設醫院實習醫師及慢性病患為研究對象，由具有多年中醫看診經驗之主治醫師分出正常人、陰陽俱虛、陰虛、陰盛、陽虛及陽盛等六組受測者，個別記錄其仰躺5分鐘的心電圖信號，每組收集八例。研究結果顯示，在時域分析部分，僅陰陽俱虛與正常人在心率方面有顯著不同，而在正常心跳間的標準差上，陰陽俱虛和陽盛兩者與正常人會有相當明顯的差異，至於在整體心率變異信號中正常心跳間超過50ms所佔的比例上，除陰虛外其餘各組皆與正常人有顯著差異。在頻域分析方面，正常人與陰陽俱虛及陽虛的低高頻功率比在統計上並無明顯差異，但是陰陽俱虛的體質其頻譜的功率明顯比正常人來的小，而陽虛者之總功率則較正常人來的大，另外在陰虛與陽盛的體質中，低頻功率明顯大於高頻功率，而在陽虛與陰盛的體質上，則高頻功率明顯大於低頻功率。
In this paper, a heart rate variability (HRV) analysis system was developed. It was applied to assess the yin-yang constitution in Chinese medicine. Six groups of subjects including normal, yin-yang exhaustion, yin exhaustion, yin repletion, yang exhaustion and yang repletion were recruited from the internal department of Chinese medicine at China Medical College Hospital. Each group comprised of eight subjects. ECG signals were acquired from all subjects for period of approximately five minutes in the supine position. The results showed in time-domain analysis that only the heart rate of yin-yang exhaustion was significantly different from that in the normal group. Standard deviation of normal to normal internal (SDNN) was significantly different between the groups of yin-yang exhaustion and normal, yang repletion and normal. The proportion derived by dividing the number of interval differences of successive NN intervals greater than 50ms by the total number of NN intervals (pNN50%) was different from any test group with normal except for the yin exhaustion group. In frequency-domain analysis, the normal case and Yin-Yang exhaustion achieved the LF/HF ratio approximate to 1. However the total power of yin-yang exhaustion had smaller value than that in the normal case. The LF power was larger than HF power in yin exhaustion and yang repletion constitutions. Conversely, the HF power was larger than LF power in yin repletion and yang exhaustion constitutions.
關聯:
Journal of Medical and Biological Engineering 22(S)91 ~98
