電針對糖尿病與正常鼠心電圖及體溫之影響; The influence of electroacupuncture on EKG and temperature under diabetic and normal rat

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Title:	電針對糖尿病與正常鼠心電圖及體溫之影響;The influence of electroacupuncture on EKG and temperature under diabetic and normal rat
Authors:	鄭鴻強;Hung-Chiang Cheng
Contributors:	中國醫藥大學：針灸研究所
Keywords:	電針;心電圖;足三里;糖耐量試驗;electro-acupuncture (EA);electrocardiogram (EKG);zusanli acupoint;intravenous glucose tolerance test (IVGTT).
Date:	2008-06-03
Issue Date:	2009-08-11 14:24:07 (UTC+8)
Abstract:	中醫利用針灸治療疾病已經有幾千年的歷史，但是它的機轉，仍然不明，雖然有多種學說來解釋包括，門閥控制學說、雙門閥控制學說、神經生理、神經化學、神經內分泌、體液學說等，並且其作用在不同臟腑或器官有不同的功能，如心臟血管系統、骨骼肌肉系統、內分泌系統、神經系統、呼吸系統等，本研究就是延續，針灸對內分泌系統的進一步探討。糖尿病第1次進入國人十大死因是在民國七十二年，並在民國九十四年進入全國十大死因之第四名，不管在臺灣和全世界其所引起的併發症已經造成嚴重的問題，甚至因為慢性病變所消耗的醫療費用越來越高，對國家的經濟發展造成一定比例的影響。糖尿病有隱形殺手之稱，不只在臺灣或美國等先進國家其發生率已經很高，而且發病年齡有越來越年輕化的趨勢，更因為醫療技術的發達，人類的壽命越來越長，伴隨而來的問題也越來越嚴重，如慢性病的增加造成個人經濟上的損失、身體行動和功能上的不便、甚至因為以上因素造成國家生產力的下降和競爭力的低落等。其引起疾病的原因大部分都是因為血中葡萄糖濃度太高，進入週邊組織的葡萄糖太少，高血糖造成組織脫水，使血液太黏稠，降低血液在血管中的流速，由於血中高濃度的膽固醇與其他脂質類的影響，進一步造成血管的收縮度下降，使血管變得脆弱，改變血管的滲透性，而造成血壓的控制不易，進一步影響自律神經甚至心臟的跳動。本研究希望能延續過去對於電針影響胰島素敏感度等的發現，藉由心電圖及體溫等生理指標的變化，探討電針對葡萄糖耐量試驗之影響，同時瞭解正常與糖尿病病態模式生理指標的差異。我們將Wistar健康鼠及STZ糖尿病鼠在靜脈注射生理食鹽水(saline) 和糖耐量試驗下 (IVGTT) 電針足三里15 Hz與不電針的心電圖和體溫作比較。結果顯示，糖尿病鼠和正常鼠的生理指標(心跳、體溫、R-R間距)有明顯的差異。糖尿病鼠的心跳速率比正常鼠慢，其體溫也較低。短期電針針刺可提昇糖尿病鼠心率達正常鼠水平，但在(IVGTT)下則無此現象，是否與葡萄糖負荷刺激副交感活性有關，須進一步探討。至於電針對交感和副交感作用之影響，可能須要利用心率變異性的差異進一步研究和討論。 Acupuncture had been used to treat diseases for several thousand years, and there were a variety of theories to explain the mechanisms of acupuncture, including gate control theory, double gate control theory, neuro-physiological effect, neuro-chemical effect、neuro-endocrinological effect and humeral mechanism, but its mechanisms are still unknown. The different functions and different actions of acupuncture were noted when acupuncture was used to treat the diseases. this study is the continuation of acupuncture’s effect on the diabetes mellitus (DM). The DM is ranked among the top ten of leading causes for death through out the world. The control and prevention of DM is getting more important due to its complications and disability which made huge economic loss and the cost effect of health. The cause of the illness mostly due to the high levels of plasma glucose, make the peripheral tissue dehydration, then let the blood too sticky and reduce blood flow in blood vessels. The high levels of plasma cholesterol and other lipids attach on the wall of blood vessels then decreased the vessels elastic, which change the vessel fragile and the permeability of blood vessels, thus difficult to control blood pressure. Further, the acupuncture affect the autonomic nervous even heart beat. In this study, we would like to investigate EA stimulation on STZ and normal rat to explore the physiological changes of electrocardiogram (EKG) and body temperature. Male healthy Wistar and STZ induced diabetic rats were used in this study. Under anesthesia by pentobarbital (40 mg/Kg, i.p.), we will proceed two major experiments, the one is under saline and the other is under intravenous-glucose-tolerance-test (IVGTT) background, Then the rats will divided into experimental group (EG) treating 15 Hz electroacupuncture (EA) on bilateral zusanli acupoint for 60 min and control group (CG) not treating EA for the same time. We will compare the effect of electrocardiogram (EKG) and body temperature between different animal models and different treatments (EG and CG) by time in 90-min observation. As the results showed, STZ and wistar rats’ physiological indicators (heart rate, body temperature, RR interval) had significant differences. The STZ rats’ heart rate was slower than wistar rats’, and their body temperature was also lower than wistar rats. The short-period of EA can elevate STZ rats’ heart rate closer to the wistar rats’. During the IVGTT, these phenomenon was not significant, it’s may be the load of the glucose under IVGTT that stimulate the parasympathetic activity. The role of acupuncture’s effects on sympathetic and parasympathetic nerve may use the heart rate variability (HRV) for further analysis.
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