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http://ir.cmu.edu.tw/ir/handle/310903500/46111
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| 題名: | 沙參麥冬湯對接受放化療之頭頸部癌患者生活品質、血中銅鋅硒離子濃度及中醫體質之影響
Effects of Sha-Sheng-Mai-Dong-Tang on Quality of Life, Serum Cooper, Zinc, and Selenium, and Body Constitution in Head and Neck Cancer Patients Receiving the Radiotherapy and Chemotherapy |
| 作者: | 蘇慶豐;Su, Ching-Feng |
| 貢獻者: | 中醫學系碩士班 |
| 關鍵詞: | 癌症患者;生活品質;微量元素;中醫體質;cancer patients;quality of life;blood;trace element;body constitution |
| 日期: | 2012-06-29 |
| 上傳時間: | 2012-08-31 16:18:08 (UTC+8) |
| 出版者: | 中國醫藥大學 |
| 摘要: | 研究目的
本研究沙參麥冬湯對接受放射線及化學治療之頭頸部癌病患，以隨機分配方式，比較研究實驗組與對照組癌症病患中醫體質特性變化，並比較介入前、後實驗組與對照組癌症病患血液中銅、鋅、硒離子濃度與生活品質之差異。
研究方法
本研究採隨機編組及單盲臨床實驗，共收錄70例頭頸部癌患者，完成全部療程並可分析者42例，實驗組22人及對照組20人，實驗組給予沙參麥冬湯，對照組給予1/10沙參麥冬湯。
研究結果
1.在生活品質方面，實驗組與對照組相較在身體功能(p=0.026)、疲勞(p=0.019)、噁心嘔吐(p=0.011)、呼吸困難(p=0.021)及整體生活品質(p=0.016)等症狀均有明顯的進步。
2.在血中銅、鋅、硒濃度方面，實驗組與對照組比較，實驗組銅離子明顯下降之趨勢(p<0.001)，鋅及硒離子有明顯上升之趨勢(兩者皆p<0.001)。
3.中醫體質評估方面，實驗組與對照組相比，後測陽氣虛(p=0.004)、陰血虛(p=0.013)、痰滯血瘀體質(p=0.047)及整體體質(p=0.005)皆有顯著之差異。
Aim
The present RCT clinical study is to evaluate the effects of Sha-Sheng-Mai-Dong-Tang in the head & neck cancer patients receiving the radiotherapy and chemotherapy. We are going to assess the clinical evaluation among the serum cooper, zinc, and selenium during treatment, and to estimate the quality of life (EORTC: QLQ-C30) and body constitution (BCQ) during the period of radiotherapy and chemotherapy on the basis of Chinese Medicine Theory.
Method
There were 70 patients entered to our clinical trial. 42 cases have completed course and were analyzed included 22 cases of experimental group and 20 cases of control group. Experimental group were treated with Sha-Sheng-Mai-Dong-Tang where control group were treated with 1/10 Sha-Sheng-Mai-Dong-Tang.
Result
1.In the respect of quality of life, experimental group had significantly better quality of life in health function(p=0.026), fatigue(p=0.019), nausea and vomiting(p=0.011), dyspnea(p=0.021), and whole quality of life(p=0.016) compared with control group.
2.The analysis of Serum Cu, Zn, and Se in experimental group, compared with control group, experimental group was on the downside in serum cooper (p<0.001)and had a trend of escalation in serum zinc and selenium(both p<0.001).
3.In the respect of body constitution, experimental group gave better score than control in Yang-Xu(p=0.004), Ying-Xu(p=0.013), phlegm stagnates(p=0.047), and whole body constitution(p=0.005) in post-test. |
| 顯示於類別: | [中醫學系暨碩博班] 博碩士論文
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