中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/41475
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 29490/55136 (53%)
Visitors : 1500310      Online Users : 433
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/41475


    Title: 蛇床子素之超臨界抽提及其奈米膠漿製備
    Extraction of Osthole by Supercritical Fluid Method and Preparation of Its Nanoemulsion
    Authors: 張釗愷
    Contributors: 藥學系碩士班
    Keywords: 蛇床子素;超臨界流體 osthole;super critical fluid
    Date: 2011-07-26
    Issue Date: 2011-10-17 17:04:03 (UTC+8)
    Publisher: 中國醫藥大學
    Abstract: 本研究目的在於評估以超臨界流體(Super critical Fluid, SCF)抽提中藥材蛇床子果實中的蛇床子素(Osthole)，評估各種超臨界抽提變因，並予以最佳化。本研究以二氧化碳作為超臨界流體，評估五種超臨界流體變因分別是夾帶劑、抽提次數、壓力、靜態抽提時間與溫度。以高效率液相層析儀測定抽提效率，固定相為RP-C18管柱，移動相為甲醇:水=7:3，發光二列陣檢測器，最大吸光波長323 nm。最佳化條件為：抽取5公克蛇床子藥材時加甲醇5 mL為夾帶劑，萃取管溫度為攝氏100 ℃，抽提壓力設為0.5 Mpa，靜態抽提時間120分鐘，動態抽提時間20分鐘，反覆以超臨界流體抽提5次；蛇床子素奈米膠漿製備，以卡波姆940的膠體0.25%的濃度，含有蛇床子素0.04%，可使奈米化的蛇床子素維持在奈米等級粒徑的時間較長且不易析出。
    This study’s purpose is to estimate using supercritical fluid for extracting Osthole from Cnidium monnieri, compare all those extraction factors and to optimize extraction factors. Use carbon dioxide as a supercritical fluid and estimate five extraction factors as co-solvent, number of extraction, pressure, stastic extraction time and temperature. Used high performance liquid chromatography to detect extraction effect, stastic phase is RP-C18 column and mobile phase MeOH: water=7:3, photo diode array detector set by max absorption wavelength 323 nm. Optimize Result: 5 g herb adds 5 mL MeOH as co-solvent, extraction cube temperature 100℃, extraction pressure 0.5 MPa, extraction time 2 hrs, repeat for 5 times of extraction. Preparation of Osthole nanoemulsion is using 0.25% Carbomer 940 and contain 0.04% Osthole, this condition can maintain nanofabrication’s Osthole in nano level’s particle size for longer time and not easy to dissolve out.
    Appears in Collections:[School of Pharmacy/Master Degree Program, Ph. D program] Theses & dissertations

    Files in This Item:

    File Description SizeFormat
    cmu-100-9871002-1.pdf5680KbAdobe PDF176View/Open
    index.html0KbHTML8View/Open


    All items in CMUR are protected by copyright, with all rights reserved.

     

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback