中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/34942
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    题名: Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo
    作者: 宋祖瑩(Tuzz-Ying Song)*;(Chien-Lin Chen);(Jiunn-Wang Liao);歐秀中(Hsiu-Chung Ou);(Ming-Shiun Tsai)
    贡献者: 物理治療學系
    关键词: Ergothioneine;Cisplatin;Avoidance tests;Neuron cells;Acetylcholinesterase activity;Oxidative stress
    日期: 2010-12
    上传时间: 2010-11-19 16:54:53 (UTC+8)
    摘要: The neuroprotective effects of ergothioneine (EGT) against cisplatin toxicity were investigated both
    in vitro and in vivo. For in vitro study, two types of neuronal cells, primary cortical neuron (PCN) cells
    and rat pheochromocytoma (PC12) cells, were incubated with EGT (0.1–10.0 lM) for 2 h followed by
    incubation with 0.5 lM cisplatin for 72 h. Results show that cisplatin markedly decreased the proliferation
    of PC12 cells and strongly inhibited the growth of axon and dendrite of PCN cells, but these effects
    were significantly prevented by EGT. For in vivo study, CBA mice were orally administered with 2 or 8 mg
    EGT/kg body weight for 58 consecutive days and were injected i.p. with 5 mg cisplatin/kg body weight on
    days 7, 9 and 11. We found that EGT significantly restored the learning and memory deficits in mice treated
    with cisplatin evaluated by active and passive avoidance tests. EGT also significantly prevented brain
    lipid peroxidation, restored acetylcholinesterase (AChE) activity and maintained glutathione/glutathione
    disulfide ratio in brain tissues of mice treated with cisplatin. These results demonstrate that EGT protects
    against cisplatin-induced neuronal injury and enhances cognition, possibly through the inhibition of
    oxidative stress and restoration of AChE activity in neuronal cells.
    關聯: FOOD AND CHEMICAL TOXICOLOGY 48(12):3492-3499
    显示于类别:[物理治療學系暨復健科學碩士班] 期刊論文

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