Stromal cell-derived factor (SDF)-1α is involved in the trafficking of hematopoietic stem cells from bone marrow to peripheral blood, and its expression is increased in the penumbra of the ischemic brain. In this study, SDF-1α was found to exert neuroprotective effects that rescued primary cortical cultures from H2O2 neurotoxicity, and to modulate neurotrophic factor expression. Rats receiving intracerebral administration of SDF-1α showed less cerebral infarction due to up-regulation of antiapoptotic proteins, and they had improved motor performance. SDF-1α injection enhanced the targeting of bone marrow (BM)-derived cells to the injured brain, as demonstrated in green fluorescent protein-chimeric mice with cerebral ischemia. In addition, increased vascular density in the ischemic cortex of SDF-1α-treated rats enhanced functional local cerebral blood flow. In summary, intracerebral administration of SDF-1α resulted in neuroprotection against neurotoxic insult, and it induced increased BM-derived cell targeting to the ischemic brain, thereby reducing the volume of cerebral infarction and improving neural plasticity.
關聯:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 324(2):834~849
