Stromal Cell-Derived factor-1 alpha promotes neuroprotection angiogenesis, and mobilization/homing of bone marrow-derived cells in Stroke rats

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 臨床醫學研究所 > 期刊論文 > Item 310903500/3381

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题名:	Stromal Cell-Derived factor-1 alpha promotes neuroprotection angiogenesis, and mobilization/homing of bone marrow-derived cells in Stroke rats
作者:	徐偉成(Woei-Cherng Shyu);林欣榮(Shinn-Zong Lin);顏寶勝(Pao-Sheng Yen);蘇靜媛(Ching-Yuan Su);陳德誠(Der-Cherng Chen);王孝榮(Hsiao-Jung Wang);李鴻(Hung Li)*
贡献者:	醫學院臨床醫學研究所;中國附醫神經部
日期:	2008-02
上传时间:	2009-08-20 18:38:10 (UTC+8)
摘要:	Stromal cell-derived factor (SDF)-1α is involved in the trafficking of hematopoietic stem cells from bone marrow to peripheral blood, and its expression is increased in the penumbra of the ischemic brain. In this study, SDF-1α was found to exert neuroprotective effects that rescued primary cortical cultures from H2O2 neurotoxicity, and to modulate neurotrophic factor expression. Rats receiving intracerebral administration of SDF-1α showed less cerebral infarction due to up-regulation of antiapoptotic proteins, and they had improved motor performance. SDF-1α injection enhanced the targeting of bone marrow (BM)-derived cells to the injured brain, as demonstrated in green fluorescent protein-chimeric mice with cerebral ischemia. In addition, increased vascular density in the ischemic cortex of SDF-1α-treated rats enhanced functional local cerebral blood flow. In summary, intracerebral administration of SDF-1α resulted in neuroprotection against neurotoxic insult, and it induced increased BM-derived cell targeting to the ischemic brain, thereby reducing the volume of cerebral infarction and improving neural plasticity.
關聯:	JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 324(2):834~849
显示于类别:	[臨床醫學研究所] 期刊論文

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