Objectives: Hot flush is the leading cause of postmenopausal women to seek for medical intervention in Taiwan. The goal of this study was to analyze the potential risk factors determining no improvements after hormone therapy for postmenopausal women with hot flushes.
Methods: We reviewed the postmenopausal women who suffered from moderate to severe hot flushes under hormone therapy from Jan.1, 2008 to Dec.31, 2008 at Taoyuan Veterans Hospital. The evaluations included the result of pelvic examination and Pap smear, gynecologic sonography, serum level of triglyceride, total cholesterol, glucose-AC, ALT and AST before hormone therapy. The definition of “no improvement” is the score of “hot flush” does not decrease after hormone therapy.
Results: 6 of the 120 women were not improved in hot flush (5%) after hormone therapy for at least 3 months. Using multivariable logistic regression analyses, the 45 – 54 years-old age and inflammation or atrophy of Pap smear result were significantly associated with no improvements after hormone therapy for postmenopausal women with hot flush.
Conclusions: Our results showed that 45 – 54 years-old age and inflammation or atrophy of Pap smear result seem to be associated with no improvements after hormone therapy for postmenopausal women with hot flush.
