使用荷爾蒙治療更年期婦女熱潮紅症狀未改善的相關原因分析;
Analysis of Risk Factors Associated with No Improvements after Hormone Replacement Therapy for Postmenopausal Women with Hot Flush

CMUR > College of Chinese Medicine > Graduate Institute of Integrated Medicine > Theses & dissertations > Item 310903500/332

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Title:	使用荷爾蒙治療更年期婦女熱潮紅症狀未改善的相關原因分析;Analysis of Risk Factors Associated with No Improvements after Hormone Replacement Therapy for Postmenopausal Women with Hot Flush
Authors:	黃景瑩;Ching-Ying Huang
Contributors:	中國醫藥大學：中西醫結合研究所碩士班
Keywords:	更年期;熱潮紅;荷爾蒙治療;停經後;Hormone therapy;Climacteric syndrome;Hot flush;Postmenopause
Date:	2009-07-24
Issue Date:	2009-08-06 11:02:44 (UTC+8)
Abstract:	目的：更年期前後婦女常因體內雌激素分泌不足而有熱潮紅、失眠、情緒不穩、失落感、陰道乾澀等更年期症候群現象產生，其中以熱潮紅最為明顯及造成台灣婦女的困擾。本研究將針對停經後婦女有更年期症狀接受荷爾蒙療法後，而自覺熱潮紅症狀未改善，進行相關危險因子的分析。方法：本試驗採病歷回溯方式，分析自2008年1月1日起至2008年12月31日止，停經後婦女初次就診時有明顯更年期症狀且未接受過荷爾蒙療法者，在桃園榮民醫院就診的病歷。所需回溯的病歷內容包括：治療前的骨盆腔內診及子宮頸抹片檢查結果、婦科超音波檢查結果、及血清生化值檢驗結果。並分析治療前後雌激素缺乏症狀自我評估表填寫結果。結果：共篩選出120位婦女進入本試驗，其中有6位服用荷爾蒙治療後其熱潮紅症狀未明顯改善（無效組，6/120 = 5%），114位服用荷爾蒙治療後其熱潮紅症狀明顯改善（有效組，114/120 = 95%）。研究顯示年齡介於45至54歲及子宮頸抹片檢查結果為發炎或萎縮，與使用荷爾蒙治療熱潮紅症狀未改善有顯著地相關。結論：本研究顯示，停經後婦女使用荷爾蒙治療熱潮紅症狀未改善的危險因子是年齡介於45至54歲及子宮頸抹片檢查結果為發炎或萎縮。 Objectives: Hot flush is the leading cause of postmenopausal women to seek for medical intervention in Taiwan. The goal of this study was to analyze the potential risk factors determining no improvements after hormone therapy for postmenopausal women with hot flushes. Methods: We reviewed the postmenopausal women who suffered from moderate to severe hot flushes under hormone therapy from Jan.1, 2008 to Dec.31, 2008 at Taoyuan Veterans Hospital. The evaluations included the result of pelvic examination and Pap smear, gynecologic sonography, serum level of triglyceride, total cholesterol, glucose-AC, ALT and AST before hormone therapy. The definition of “no improvement” is the score of “hot flush” does not decrease after hormone therapy. Results: 6 of the 120 women were not improved in hot flush (5%) after hormone therapy for at least 3 months. Using multivariable logistic regression analyses, the 45 – 54 years-old age and inflammation or atrophy of Pap smear result were significantly associated with no improvements after hormone therapy for postmenopausal women with hot flush. Conclusions: Our results showed that 45 – 54 years-old age and inflammation or atrophy of Pap smear result seem to be associated with no improvements after hormone therapy for postmenopausal women with hot flush.
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