Because of mandibular movement would affect by the morphology of glenoid fossa. Furthermore, oral prosthesis would affect by mandibular movement. The purpose of this study was to measure the anterior, posterior, medial, and lateral inclinations of glenoid fossa, furthermore, evaluate the effect of the gender, age, and asymmetry of right and left side on the inclinations of the glenoid fossa. To establish an scientific data for clinical application. The head computed tomography images of the 198 Asians (95 females aged 44.2?b20.7 years, range 11–88 years; and 103 males aged 44.5?b19.7 years, range 15–98 years) were selected from the radiology department of China Medical University and Medical Center. All of computed tomography images were reoriented with it midline perpendicular to the screen, with it Frankford plane parallel to the horizontal plane. Eight parameters of inclinations of glenoid fossa were measured by medical image software: anterior inclination in left side and right side on sagittal view; posterior inclination in left side and right side on sagittal view; medial inclination in left side and right side on coronal view; lateral inclination in left side and right side on coronal view. According to the protocol above, statistical analysis shows that males exhibited significant steeper angles than females in the anterior inclination in both left and right sides. A moderate positive correlation was found between age and anterior inclination in left side and right side. The other parameters were not significant affected by the age and gender. In male, female, and both groups, there were no significant differences between right and left glenoid fossa in all parameters. The effect of age and gender were mainly affected the anterior inclination of the glenoid fossa. In addition, there was symmetry between right and left inclinations of glenoid fossa.