CPAP is a cell-cycle regulated protein that controls centriole length

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 免疫學研究所 > 期刊論文 > Item 310903500/31147

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题名:	CPAP is a cell-cycle regulated protein that controls centriole length
作者:	唐張潔如(Chieh-Ju C. Tang);傅如輝(Ru-Huei Fu);吳國盛(Kuo-Sheng Wu);許文彬(Wen-Bin Hsu);唐堂(Tang K. Tang)*
贡献者:	醫學院免疫學研究所;中國附醫神經精神醫學中心
日期:	2009-07
上传时间:	2010-09-27 15:43:02 (UTC+8)
摘要:	Centriole duplication involves the growing of a procentriole (progeny centriole) next to the proximal end of each pre-existing centriole (parental centriole). The molecular mechanisms that regulate procentriole elongation remain obscure. We show here that expression of the centriolar protein CPAP (centrosomal P4.1-associated protein) is carefully regulated during the cell cycle, with the protein being degraded in late mitosis. Depletion of CPAP inhibited centrosome duplication, whereas excess CPAP induced the formation of elongated procentriole-like structures (PLSs), which contain stable microtubules and several centriolar proteins. Ultrastructural analysis revealed that these structures are similar to procentrioles with elongated microtubules. Overexpression of a CPAP mutant (CPAP-377EE) that does not bind to tubulin dimers significantly inhibited the formation of CPAP-induced PLSs. Together, these results suggest that CPAP is a new regulator of centriole length and its intrinsic tubulin-dimer binding activity is required for procentriole elongation.
關聯:	NATURE CELL BIOLOGY 11(7):825-831
显示于类别:	[免疫學研究所] 期刊論文

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