The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils

CMUR > College of Pharmacy > Graduate Institute of Pharmaceutical Chemistry > Journal articles > Item 310903500/30940

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/30940

Title:	The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils
Authors:	Wang, JP;Tsao, LT;Raung, SL;Lin, CN
Contributors:	藥學院藥化所;Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Kaohsiung Med Coll, Sch Pharm, Kaohsiung, Taiwan
Date:	1998
Issue Date:	2010-09-24 15:07:02 (UTC+8)
Publisher:	STOCKTON PRESS
Abstract:	The effect of Jen-San-Yaung-Jung-Tang (YJT) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that YJT (0.5 and 1.0 g/kg) significantly improved SCOP-induced amnesia and did not change the horizontal activity and pain threshold. YJT at 0.5 and 1.0 g/kg also did not change SCOP-treated horizontal activity and pain threshold. Furthermore, the antiamnesic effect of YJT at 1.0 g/kg on the SCOP-induced amnesia was augmented by physostigmine, but was not altered by neostigmine or scopolamine N-methylbromide. These results suggest that the antiamnesic effect of YJT could only be related to the memory-related process, and to an increase in central cholinergic neuronal activity.
Relation:	BRITISH JOURNAL OF PHARMACOLOGY 125(3):517-525
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

Files in This Item:

There are no files associated with this item.