Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 中國藥學研究所(已停用) > 期刊論文 > Item 310903500/30807

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题名:	Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells
作者:	Yang, SE;Hsieh, MT;Tsai, TH;Hsu, SL
贡献者:	藥學院中藥所;Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 40705, Taiwan;Natl Res Inst Chinese Med, Taipei 11221, Taiwan;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung, Taiwan
日期:	2003
上传时间:	2010-09-24 15:02:08 (UTC+8)
出版者:	NATURE PUBLISHING GROUP
摘要:	The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphisms of cDNA in 25 AD patients and 100 healthy controls by single-strand conformational polymorphism. A polymorphism at BACE coding region was identified and confirmed to be 786C/G polymorphism by nucleotide sequencing. Based on these findings, we investigated the association of this polymorphism with the occurrence of AD by PCR-RFLP. A total of 98 AD patients along with 138 controls were recruited in the present study. The allele frequencies of the 786C/G polymorphism were 0.622 for C and 0.378 for G in AD. In controls, the C and G allele frequencies were 0.691 and 0.309, respectively. No significant association of this polymorphism with the occurrence of AD can be established.. Larger sample size may be necessary to identify other potential mutations/polymorphisms among BACE gene. (C) 2002 Elsevier Science B.V. All rights reserved.
關聯:	BRITISH JOURNAL OF PHARMACOLOGY 138(1):193-201
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

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