Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells

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Title:	Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells
Authors:	Yang, SE;Hsieh, MT;Tsai, TH;Hsu, SL
Contributors:	藥學院中藥所;Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 40705, Taiwan;Natl Res Inst Chinese Med, Taipei 11221, Taiwan;China Med Coll, Inst Chinese Pharmaceut Sci, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 15:02:08 (UTC+8)
Publisher:	NATURE PUBLISHING GROUP
Abstract:	The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphisms of cDNA in 25 AD patients and 100 healthy controls by single-strand conformational polymorphism. A polymorphism at BACE coding region was identified and confirmed to be 786C/G polymorphism by nucleotide sequencing. Based on these findings, we investigated the association of this polymorphism with the occurrence of AD by PCR-RFLP. A total of 98 AD patients along with 138 controls were recruited in the present study. The allele frequencies of the 786C/G polymorphism were 0.622 for C and 0.378 for G in AD. In controls, the C and G allele frequencies were 0.691 and 0.309, respectively. No significant association of this polymorphism with the occurrence of AD can be established.. Larger sample size may be necessary to identify other potential mutations/polymorphisms among BACE gene. (C) 2002 Elsevier Science B.V. All rights reserved.
Relation:	BRITISH JOURNAL OF PHARMACOLOGY 138(1):193-201
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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