資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30750
|
| 題名: | Hydrocortisone affects the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats |
| 作者: | Chung, JG;Chen, GW;Yang, MD;Wang, DY;Hung, CF;Lin, WC;Chang, HL |
| 貢獻者: | 醫學院醫學系微生物學科;China Med Coll & Hosp, Dept Microbiol, Taichung 400, Taiwan;China Med Coll & Hosp, Dept Surg, Taichung 400, Taiwan;China Med Coll & Hosp, Dept Orthopaed, Taichung 400, Taiwan;China Med Coll & Hosp, Dept Pharmacol, Taichung 400, Taiwan;Jen Ai Hosp, Dept Surg, Taichung 400, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 15:01:05 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | In this study, we attempted to identify the interactions and mechanisms between veratrine and paeoniflorin on isolated mouse vas deferens. Paeoniflorin had no effect on isolated mouse vas deferens. Veratrine (I x 10(-5) similar to 1 x 10(-3) g/ml) could directly induce contraction of isolated rat and mouse vas deferens. The concentration induced by veratrine (1 x 10(-5) g/ml) was completely inhibited by Ca2+-free solution and verapamil (1 x 10(-5) M), in both the epididymal and the prostatic portions of isolated mouse vas deferens. Naloxone (1 x 10(-5) M) did not alter the contraction induced by veratrine (1 x 10(-5) g/ml) in either the epididymal or the prostatic portions of isolated mouse vas deferens. Paeoniflorin (4.8 x 10(-5) g/ml) inhibited the contraction induced by veratrine (1 x 10(-5) g/ml) in both the epididymal and the prostatic portions of isolated mouse vas deferens. Paeoniflorin (4.8 x 10(-5) g/ml) potentiated norepinephrine (I x 10(-5) M)-induced phasic contraction in the epididymal portion, but decreased contractions in the prostatic portion. Paeoniflorin (4.8 x 10(-5) g/ml) increased KCl (56 mM)-induced phasic contraction in the epididymal portion, but decreased the tonic contraction in either the epididymal or the prostatic portion. Veratrine (I x 10(-5) g/ml)-induced contractions could be decreased by pretreatment with ryanodine (1 X 10(-5) M) in both the epididymal and the prostatic portions. Pretreatment with the combination of paeoniflorin (4.8 x 10(-5) g/ml) and ryanodine (1 X 10(-5) M) did not potentiate the inhibition of paeoniflorin in the veratrine-induced contraction in both the epididymal and the prostatic portions of isolated mouse vas deferens. |
| 關聯: | ANTICANCER RESEARCH 22(3):1641-1647 |
| 顯示於類別: | [醫學系] 期刊論文
|
在CMUR中所有的資料項目都受到原著作權保護.
|
