Hydrocortisone affects the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats

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Title:	Hydrocortisone affects the N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in Sprague-Dawley rats
Authors:	Chung, JG;Chen, GW;Yang, MD;Wang, DY;Hung, CF;Lin, WC;Chang, HL
Contributors:	醫學院醫學系微生物學科;China Med Coll & Hosp, Dept Microbiol, Taichung 400, Taiwan;China Med Coll & Hosp, Dept Surg, Taichung 400, Taiwan;China Med Coll & Hosp, Dept Orthopaed, Taichung 400, Taiwan;China Med Coll & Hosp, Dept Pharmacol, Taichung 400, Taiwan;Jen Ai Hosp, Dept Surg, Taichung 400, Taiwan
Date:	2002
Issue Date:	2010-09-24 15:01:05 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	In this study, we attempted to identify the interactions and mechanisms between veratrine and paeoniflorin on isolated mouse vas deferens. Paeoniflorin had no effect on isolated mouse vas deferens. Veratrine (I x 10(-5) similar to 1 x 10(-3) g/ml) could directly induce contraction of isolated rat and mouse vas deferens. The concentration induced by veratrine (1 x 10(-5) g/ml) was completely inhibited by Ca2+-free solution and verapamil (1 x 10(-5) M), in both the epididymal and the prostatic portions of isolated mouse vas deferens. Naloxone (1 x 10(-5) M) did not alter the contraction induced by veratrine (1 x 10(-5) g/ml) in either the epididymal or the prostatic portions of isolated mouse vas deferens. Paeoniflorin (4.8 x 10(-5) g/ml) inhibited the contraction induced by veratrine (1 x 10(-5) g/ml) in both the epididymal and the prostatic portions of isolated mouse vas deferens. Paeoniflorin (4.8 x 10(-5) g/ml) potentiated norepinephrine (I x 10(-5) M)-induced phasic contraction in the epididymal portion, but decreased contractions in the prostatic portion. Paeoniflorin (4.8 x 10(-5) g/ml) increased KCl (56 mM)-induced phasic contraction in the epididymal portion, but decreased the tonic contraction in either the epididymal or the prostatic portion. Veratrine (I x 10(-5) g/ml)-induced contractions could be decreased by pretreatment with ryanodine (1 X 10(-5) M) in both the epididymal and the prostatic portions. Pretreatment with the combination of paeoniflorin (4.8 x 10(-5) g/ml) and ryanodine (1 X 10(-5) M) did not potentiate the inhibition of paeoniflorin in the veratrine-induced contraction in both the epididymal and the prostatic portions of isolated mouse vas deferens.
Relation:	ANTICANCER RESEARCH 22(3):1641-1647
Appears in Collections:	[School of Medicine] Journal articles

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