Inverse expression of dihydrodiol dehydrogenase and glutathione-s-transferase in patients with esophageal squamous cell carcinoma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30674

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题名:	Inverse expression of dihydrodiol dehydrogenase and glutathione-s-transferase in patients with esophageal squamous cell carcinoma
作者:	Wang, LS;Chow, KC;Wu, YC;Lin, TY;Li, WY
贡献者:	附設醫院醫研部;Taipei Vet Gen Hosp, Dept Surg, Div Thorac Surg, Taipei, Taiwan;Natl Yang Ming Univ, Taipei 112, Taiwan;Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung, Taiwan;China Med Coll, Med Res Inst, Taichung, Taiwan;China Med Coll Hosp, Dept Surg, Taichung, Taiwan;China Med Coll Hosp, Dept Pathol, Taichung, Taiwan
日期:	2004
上传时间:	2010-09-24 14:59:48 (UTC+8)
出版者:	WILEY-LISS
摘要:	Parvovirus B19 (PVB19) infection can induce transient anaemia in patients with increased erythropoiesis. However, the dynamic change within the bone marrow after PVB19 infection is not well understood. Increased erythropoiesis is a physiological phenomenon in puerperital women. Nevertheless, anaemia as a result of PVB19 infection in puerperital women has never been reported. We report one patient with eclampsia and two patients with pre-eclampsia who had transient, severe anaemia during the puerperital period because of PVB19 infection. Viral genomes were detected in the peripheral blood during the anaemic period by polymerase chain reaction and became undetectable after the anaemia was resolved. Viral genomes and protein could also be detected in bone marrow by in situ hybridization and immunohistochemical staining, respectively. Serial aspiration cytology of bone marrow showed severe dysplastic change involving erythroid precursors with a few apoptotic cells at the initial onset of anaemia, markedly increased apoptotic cells that was confirmed by the increased expression of activated caspase 3, around the nadir of anaemia, and a normal marrow picture without features of apoptosis after recovery from anaemia. Our data indicates that PVB19 infection can induce transient, severe dyserythropoietic anaemia in puerperital women with pre-eclampsia/eclampsia and the pathogenetic mechanism may probably involve the induction of apoptosis following PVB19 infection.
關聯:	INTERNATIONAL JOURNAL OF CANCER 111(2):246-251
显示于类别:	[台中附設醫院] 期刊論文

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