Inverse expression of dihydrodiol dehydrogenase and glutathione-s-transferase in patients with esophageal squamous cell carcinoma

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/30674

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/30674

Title:	Inverse expression of dihydrodiol dehydrogenase and glutathione-s-transferase in patients with esophageal squamous cell carcinoma
Authors:	Wang, LS;Chow, KC;Wu, YC;Lin, TY;Li, WY
Contributors:	附設醫院醫研部;Taipei Vet Gen Hosp, Dept Surg, Div Thorac Surg, Taipei, Taiwan;Natl Yang Ming Univ, Taipei 112, Taiwan;Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung, Taiwan;China Med Coll, Med Res Inst, Taichung, Taiwan;China Med Coll Hosp, Dept Surg, Taichung, Taiwan;China Med Coll Hosp, Dept Pathol, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:59:48 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	Parvovirus B19 (PVB19) infection can induce transient anaemia in patients with increased erythropoiesis. However, the dynamic change within the bone marrow after PVB19 infection is not well understood. Increased erythropoiesis is a physiological phenomenon in puerperital women. Nevertheless, anaemia as a result of PVB19 infection in puerperital women has never been reported. We report one patient with eclampsia and two patients with pre-eclampsia who had transient, severe anaemia during the puerperital period because of PVB19 infection. Viral genomes were detected in the peripheral blood during the anaemic period by polymerase chain reaction and became undetectable after the anaemia was resolved. Viral genomes and protein could also be detected in bone marrow by in situ hybridization and immunohistochemical staining, respectively. Serial aspiration cytology of bone marrow showed severe dysplastic change involving erythroid precursors with a few apoptotic cells at the initial onset of anaemia, markedly increased apoptotic cells that was confirmed by the increased expression of activated caspase 3, around the nadir of anaemia, and a normal marrow picture without features of apoptosis after recovery from anaemia. Our data indicates that PVB19 infection can induce transient, severe dyserythropoietic anaemia in puerperital women with pre-eclampsia/eclampsia and the pathogenetic mechanism may probably involve the induction of apoptosis following PVB19 infection.
Relation:	INTERNATIONAL JOURNAL OF CANCER 111(2):246-251
Appears in Collections:	[China Medical University Hospital] Jurnal articles

Files in This Item:

There are no files associated with this item.

Loading...