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http://ir.cmu.edu.tw/ir/handle/310903500/30667
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| 題名: | Effects of berberine on arylamine N-acetyltransferase activity in human bladder tumour cells |
| 作者: | Chung, JG;Wu, LT;Chu, CB;Jan, JY;Ho, CC;Tsou, MF;Lu, HF;Chen, GW;Lin, JG;Wang, TF |
| 貢獻者: | 醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung 400, Taiwan;China Med Coll, Dept Physiol, Taichung 400, Taiwan;China Med Coll Hosp, Dept Clin Lab, Taichung 400, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan;China Med Coll, Grad Inst Chinese Med Sci, Taichung 400, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung 400, Taiwan |
| 日期: | 1999 |
| 上傳時間: | 2010-09-24 14:59:40 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | Paeonol was used to determine any effects on the N-acetyltransferase (NAT) activity in human colon tumour cells as measured by HPLC exhibited for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). The NAT activity in the human colon tumour intact cells and cytosols was promoted bq paeonol in a dose-dependent manner, that is, the higher the concentrations of paeonol. the higher the promotion of NAT activity. The apparent V-max values from NAT of human colon tumour cells were also promoted by paeonol in cytosols and in intact cells. The data also demonstrated that co-treatment with paeonol in the media an increase in AF-DNA adduct formation was seen in the human colon tumour cells. This report is the first demonstration to show paeonol did promote human colon tumour cell NAT activity and AF-DNA adduct formation. (C) 1999 Elsevier Science Ltd. All rights reserved. |
| 關聯: | FOOD AND CHEMICAL TOXICOLOGY 37(4):319-326 |
| 顯示於類別: | [醫學系] 期刊論文
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