Effects of berberine on arylamine N-acetyltransferase activity in human bladder tumour cells

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Title:	Effects of berberine on arylamine N-acetyltransferase activity in human bladder tumour cells
Authors:	Chung, JG;Wu, LT;Chu, CB;Jan, JY;Ho, CC;Tsou, MF;Lu, HF;Chen, GW;Lin, JG;Wang, TF
Contributors:	醫學院醫學系微生物學科;China Med Coll, Dept Microbiol, Taichung 400, Taiwan;China Med Coll, Dept Physiol, Taichung 400, Taiwan;China Med Coll Hosp, Dept Clin Lab, Taichung 400, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan;China Med Coll, Grad Inst Chinese Med Sci, Taichung 400, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung 400, Taiwan
Date:	1999
Issue Date:	2010-09-24 14:59:40 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	Paeonol was used to determine any effects on the N-acetyltransferase (NAT) activity in human colon tumour cells as measured by HPLC exhibited for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). The NAT activity in the human colon tumour intact cells and cytosols was promoted bq paeonol in a dose-dependent manner, that is, the higher the concentrations of paeonol. the higher the promotion of NAT activity. The apparent V-max values from NAT of human colon tumour cells were also promoted by paeonol in cytosols and in intact cells. The data also demonstrated that co-treatment with paeonol in the media an increase in AF-DNA adduct formation was seen in the human colon tumour cells. This report is the first demonstration to show paeonol did promote human colon tumour cell NAT activity and AF-DNA adduct formation. (C) 1999 Elsevier Science Ltd. All rights reserved.
Relation:	FOOD AND CHEMICAL TOXICOLOGY 37(4):319-326
Appears in Collections:	[School of Medicine] Journal articles

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