中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/30534
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 29490/55136 (53%)
造訪人次 : 1567584      線上人數 : 404
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    主頁登入上傳說明關於CMUR管理 到手機版
    請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/30534


    題名: THE EFFECT OF CHEMICAL SYMPATHECTOMY ON ACUTE LIVER-INJURY INDUCED BY CARBON-TETRACHLORIDE IN SPONTANEOUSLY HYPERTENSIVE RATS
    作者: HSU, CT;SHICHIJO, K;ITO, M;SEKINE, I
    貢獻者: 醫學院醫學系病理學科;HSU, CT, CHINA MED COLL,SCH MED,DEPT PATHOL,91 HSUEH SHIH RD,TAICHUNG,TAIWAN
    日期: 1993
    上傳時間: 2010-09-24 14:57:14 (UTC+8)
    出版者: ELSEVIER SCIENCE BV
    摘要: A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents (e.g. F, Cl, and OCH3) at C-6, C-7, and C-8 show, in general, potent cytotoxicity against human lung carcinoma (A-549), ileocecal carcinoma (HCT-8), melanoma (RPMI-7951), and epidermoid carcinoma of the nasopharynx (KB) and two murine leukemia lines (P-388 and L1210). Introduction of alkyl groups at N-1 or C-4 oxygen led to inactive compounds (35-43 and 50). In addition, compounds 24, 26, and 27 were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. These compounds demonstrated the most marked effects in the screen on two colon carcinoma cell lines (COLO-205 and KM-2OL2) and on a central nervous system tumor cell line (SF-539) with compound 26 the most potent of the three agents. Compounds 24, 26, and 27 were potent inhibitors of tubulin polymerization, with activity nearly comparable to that of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. The three agents also inhibited the binding of radiolabeled colchicine to tubulin, but this inhibition was less potent than that obtained with the natural products.
    關聯: JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM 43(2):91-96
    顯示於類別:[醫學系] 期刊論文

    文件中的檔案:

    沒有與此文件相關的檔案.



    在CMUR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

     


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋