THE EFFECT OF CHEMICAL SYMPATHECTOMY ON ACUTE LIVER-INJURY INDUCED BY CARBON-TETRACHLORIDE IN SPONTANEOUSLY HYPERTENSIVE RATS

CMUR > College of Medicine > School of Medicine > Journal articles > Item 310903500/30534

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/30534

Title:	THE EFFECT OF CHEMICAL SYMPATHECTOMY ON ACUTE LIVER-INJURY INDUCED BY CARBON-TETRACHLORIDE IN SPONTANEOUSLY HYPERTENSIVE RATS
Authors:	HSU, CT;SHICHIJO, K;ITO, M;SEKINE, I
Contributors:	醫學院醫學系病理學科;HSU, CT, CHINA MED COLL,SCH MED,DEPT PATHOL,91 HSUEH SHIH RD,TAICHUNG,TAIWAN
Date:	1993
Issue Date:	2010-09-24 14:57:14 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents (e.g. F, Cl, and OCH3) at C-6, C-7, and C-8 show, in general, potent cytotoxicity against human lung carcinoma (A-549), ileocecal carcinoma (HCT-8), melanoma (RPMI-7951), and epidermoid carcinoma of the nasopharynx (KB) and two murine leukemia lines (P-388 and L1210). Introduction of alkyl groups at N-1 or C-4 oxygen led to inactive compounds (35-43 and 50). In addition, compounds 24, 26, and 27 were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. These compounds demonstrated the most marked effects in the screen on two colon carcinoma cell lines (COLO-205 and KM-2OL2) and on a central nervous system tumor cell line (SF-539) with compound 26 the most potent of the three agents. Compounds 24, 26, and 27 were potent inhibitors of tubulin polymerization, with activity nearly comparable to that of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4. The three agents also inhibited the binding of radiolabeled colchicine to tubulin, but this inhibition was less potent than that obtained with the natural products.
Relation:	JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM 43(2):91-96
Appears in Collections:	[School of Medicine] Journal articles

Files in This Item:

There are no files associated with this item.

Loading...