Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia

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Title:	Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia
Authors:	Chen, CM;Lane, HY;Wu, YR;Ro, LS;Chen, FL;Hung, WL;Hou, YT;Lin, CY;Huang, SY;Chen, IC;Soong, BW;Li, ML;Hsieh-Li, HM;Su, MT;Lee-Chen, GJ
Contributors:	附設醫院精神醫學部;China Med Univ Hosp, Dept Psychiat, Taichung 404, Taiwan;Chang Gung Univ, Coll Med, Taipei 105, Taiwan;Chang Gung Mem Hosp, Dept Neurol, Taipei 105, Taiwan;Natl Taiwan Normal Univ, Dept Life Sci, Taipei 116, Taiwan;Taipei Vet Gen Hosp, Neurol Inst, Taipei 112, Taiwan;Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:52:48 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	The aim of this study was to examine whether -627 interleukin-10 (IL-10) promoter polymorphism is a marker of susceptibility to or severity of rheumatoid arthritis (RA) in Chinese patients in Taiwan. The study included 198 Chinese patients with RA. One hundred unrelated healthy individuals living in central Taiwan served as the control subjects. The relationship between IL-10 gene polymorphism and clinical manifestations of RA was evaluated. For the genotype, allelic frequency, and carriage rate of IL-10 polymorphism, there were no statistically significant differences found between patients and controls. Furthermore, we did not detect any association of IL-10 genotype with rheumatoid factor (RF), extra-articular involvement, or bone erosion in the RA patients. The lack of association of -627 IL-10 gene polymorphism with RA and the clinical findings in our study implies that the IL-10 gene polymorphism cannot serve as a candidate gene marker for screening RA patients.
Relation:	SCHIZOPHRENIA RESEARCH 78(2月3日):131-136
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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