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| 題名: | Glycine transporter I inhibitor, N-methylglycine (Sarcosine), added to antipsychotics for the treatment of schizophrenia |
| 作者: | Tsai, GC;Lane, HY;Yang, PC;Chong, MY;Lange, N |
| 貢獻者: | 附設醫院精神醫學部;McLean Hosp, Lab Mol & Psychiat Neurosci, Belmont, MA 02478 USA;McLean Hosp, Lab Stat Neuroimaging, Belmont, MA 02478 USA;Harvard Univ, Sch Med, Boston, MA 02115 USA;China Med Coll Hosp, Dept Psychiat, Taichung, Taiwan;Kaohsiung Med Univ, Dept Psychiat, Kaohsiung, Taiwan |
| 日期: | 2004 |
| 上傳時間: | 2010-09-24 14:52:34 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE INC |
| 摘要: | Human epidemiological studies suggest an association between N-acelyltransferase (NAT) activity and the incidence of bladder and colorectal cancers. In this study, paclitaxel was selected to examine the inhibition of arylamine NAT activity, gene expression and 2-aminofluorene-DNA adduct formation in a human osteogenic sarcoma cell line (U-2 OS). The activity of NAT was determined by high performance liquid chromatography (HPLC) assay for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and nonaceylated AF and PABA. Human osteogenic sarcoma cell cytosols and intact cells were used to examine the NAT activity, gene expression and AF-DNA adduct formation. The results demonstrated that NAT activity, percent of NAT in examined cells, gene expression (NAT] mRNA) and AF-DNA adduct formation in human osteogenic sarcoma cells were inhibited and decreased by paclitaxel in a dose-dependent manner. The results also demonstrated that paclitaxel decreased the apparent values of Km and Vmax from intact human osteogenic sarcoma cells (U-2 OS). Thus, paclitaxel is an uncompetitive inhibitor of the NAT enzyme. |
| 關聯: | BIOLOGICAL PSYCHIATRY 55(5):452-456 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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