Adjunctive fluvoxamine inhibits clozapine-related weight gain and metabolic disturbances

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30280

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题名:	Adjunctive fluvoxamine inhibits clozapine-related weight gain and metabolic disturbances
作者:	Lu, ML;Lane, HY;Lin, SK;Chen, KP;Chang, WH
贡献者:	附設醫院精神醫學部;China Med Univ Hosp, Dept Psychiat, Taichung 404, Taiwan;Taipei Med Univ, Dept Psychiat, Wan Fang Hosp, Taipei, Taiwan;Taipei City Psychiat Ctr, Dept Adult Psychiat, Taipei, Taiwan;Tzu Chi Univ, Hualien, Taiwan;Dalin Tzu Chi Gen Hosp, Dept Psychiat, Hualien, Taiwan
日期:	2004
上传时间:	2010-09-24 14:52:28 (UTC+8)
出版者:	PHYSICIANS POSTGRADUATE PRESS
摘要:	Application of combining herbal medicine and biomedical material science to nerve regeneration is a new approach. In this study, we describe a novel use of purified genipin, which can be extracted from Gardenia jasminoides Ellis, fixing the gelatin to be an extracellular matrix for peripheral nerve regeneration. A 10-mm gap of rat sciatic nerve was created between the proximal and distal nerve stumps, which were sutured into silicone rubber tubes filled with either the genipin-fixed gelatin or collagen gel. Silicone rubber tubes filled with saline were used as controls. Six weeks after implantation, regeneration across the nerve gaps occurred in 80 and 90% of the animals from the groups of genipin-fixed gelatin and collagen, respectively, whereas only 30% in them control group. Large numbers of myelinated axons were also seen in the genipin-fixed gelatin (5104 +/- 3278) and the collagen groups (8063 +/- 1807). These findings indicated that the genipin-fixed gelatin could be an acceptable extracellular matrix for nerve regeneration.
關聯:	JOURNAL OF CLINICAL PSYCHIATRY 65(6):766-771
显示于类别:	[台中附設醫院] 期刊論文

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