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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/30207
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| 題名: | Effect of p53 codon 72 polymorphism on p53 protein expression in pterygium |
| 作者: | Tsai, YY;Chang, KC;Lee, H;Cheng, YW;Tsai, FJ;Tseng, SH;Ao, HS;Chau, PS |
| 貢獻者: | 附設醫院眼科部;China Med Univ Hosp, Dept Ophthalmol, Taichung, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan;Chung Shan Med Univ, Inst Toxicol, Taichung, Taiwan;China Med Univ, Coll Chinese Med, Taichung, Taiwan;China Med Univ Hosp, Dept Med Genet, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Tainan 70428, Taiwan;Chung Shan Med Univ, Sch Med Technol, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:51:08 (UTC+8) |
| 出版者: | BLACKWELL PUBLISHING ASIA |
| 摘要: | A series of benzyloxybenzaldehyde derivatives were prepared and tested against the HL-60 cell line for anticancer activity. Preliminary structure-activity relationships were established. It was discovered that 2-(benzyloxy)benzaldehyde (17), 2-(benzyloxy)-4-methoxybenzaldehyde (26), 2-(benzyloxy)-5-methoxybenzaldehyde (27), 2-(benzyloxy)-5-chlorobenzaldehyde (28), 2-[(3-methoxybenzyl)oxy]benzaldehyde (29), 2-[(2-chlorobenzyl)oxy]benzaldehyde (30), and 2-[(4-chlorobenzyl)oxy]benzaldehyde (31) exhibited significant activity at 1-10 muM. Among them, compound 29 was the most potent one. The morphological assessment and DNA fragmentation analysis indicated that these compounds arrested cell cycle progression at G2/M phase and induced cell apoptosis. They resulted in the loss of mitochondrial membrane potential after 12 h of treatment. (C) 2004 Elsevier Ltd. All rights reserved. |
| 關聯: | CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 33(1):60-62 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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