Effect of p53 codon 72 polymorphism on p53 protein expression in pterygium

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Title:	Effect of p53 codon 72 polymorphism on p53 protein expression in pterygium
Authors:	Tsai, YY;Chang, KC;Lee, H;Cheng, YW;Tsai, FJ;Tseng, SH;Ao, HS;Chau, PS
Contributors:	附設醫院眼科部;China Med Univ Hosp, Dept Ophthalmol, Taichung, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan;Chung Shan Med Univ, Inst Toxicol, Taichung, Taiwan;China Med Univ, Coll Chinese Med, Taichung, Taiwan;China Med Univ Hosp, Dept Med Genet, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Tainan 70428, Taiwan;Chung Shan Med Univ, Sch Med Technol, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:51:08 (UTC+8)
Publisher:	BLACKWELL PUBLISHING ASIA
Abstract:	A series of benzyloxybenzaldehyde derivatives were prepared and tested against the HL-60 cell line for anticancer activity. Preliminary structure-activity relationships were established. It was discovered that 2-(benzyloxy)benzaldehyde (17), 2-(benzyloxy)-4-methoxybenzaldehyde (26), 2-(benzyloxy)-5-methoxybenzaldehyde (27), 2-(benzyloxy)-5-chlorobenzaldehyde (28), 2-[(3-methoxybenzyl)oxy]benzaldehyde (29), 2-[(2-chlorobenzyl)oxy]benzaldehyde (30), and 2-[(4-chlorobenzyl)oxy]benzaldehyde (31) exhibited significant activity at 1-10 muM. Among them, compound 29 was the most potent one. The morphological assessment and DNA fragmentation analysis indicated that these compounds arrested cell cycle progression at G2/M phase and induced cell apoptosis. They resulted in the loss of mitochondrial membrane potential after 12 h of treatment. (C) 2004 Elsevier Ltd. All rights reserved.
Relation:	CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 33(1):60-62
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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