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http://ir.cmu.edu.tw/ir/handle/310903500/30019
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| 題名: | Partially hyperfractionated accelerated radiotherapy and concurrent chemotherapy for advanced nasopharyngeal carcinoma |
| 作者: | Lin, JC;Chen, KY;Jan, JS;Hsu, CY |
| 貢獻者: | 醫學院醫學系;TAICHUNG VET GEN HOSP, DEPT OTORHINOLARYNGOL, TAICHUNG, TAIWAN;NATL YANG MING UNIV, INST CLIN MED, TAIPEI 112, TAIWAN;CHINA MED COLL, SCH MED, TAICHUNG, TAIWAN;TAIPEI VET GEN HOSP, CTR CANC, TAIPEI, TAIWAN |
| 日期: | 1996 |
| 上傳時間: | 2010-09-24 14:47:49 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | To evaluate the catabolic effects of dexamethasone therapy on protein metabolism, amino acid concentrations and urinary 3-methylhistidine (3MH) were measured in 28 premature infants who were included in a double-blind controlled study using early dexamethasone therapy in the prevention of bronchopulmonary dysplasia. Fifteen infants received dexamethasone (0.5 mg/kg/day i.v.) and 13 infants received normal saline as control. Heparinized venous blood samples for amino acid analysis were obtained before the study and again at day 5 after starting the study. Urinary 3MH was measured on days 1, 3, 5, 7, 14, 21, and 28 of treatment. A substantial increase in amino acid concentrations was observed in infants receiving dexamethasone. Alanine, glutamine, citrulline, ornithine and cystine concentrations increased twofold or more. The 3MH:creatinine ratio was increased in the treated group. These metabolic effects were most likely due to an increase in protein catabolism. |
| 關聯: | INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 36(5):1127-1136 |
| 顯示於類別: | [醫學系] 期刊論文
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