Partially hyperfractionated accelerated radiotherapy and concurrent chemotherapy for advanced nasopharyngeal carcinoma

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Title:	Partially hyperfractionated accelerated radiotherapy and concurrent chemotherapy for advanced nasopharyngeal carcinoma
Authors:	Lin, JC;Chen, KY;Jan, JS;Hsu, CY
Contributors:	醫學院醫學系;TAICHUNG VET GEN HOSP, DEPT OTORHINOLARYNGOL, TAICHUNG, TAIWAN;NATL YANG MING UNIV, INST CLIN MED, TAIPEI 112, TAIWAN;CHINA MED COLL, SCH MED, TAICHUNG, TAIWAN;TAIPEI VET GEN HOSP, CTR CANC, TAIPEI, TAIWAN
Date:	1996
Issue Date:	2010-09-24 14:47:49 (UTC+8)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Abstract:	To evaluate the catabolic effects of dexamethasone therapy on protein metabolism, amino acid concentrations and urinary 3-methylhistidine (3MH) were measured in 28 premature infants who were included in a double-blind controlled study using early dexamethasone therapy in the prevention of bronchopulmonary dysplasia. Fifteen infants received dexamethasone (0.5 mg/kg/day i.v.) and 13 infants received normal saline as control. Heparinized venous blood samples for amino acid analysis were obtained before the study and again at day 5 after starting the study. Urinary 3MH was measured on days 1, 3, 5, 7, 14, 21, and 28 of treatment. A substantial increase in amino acid concentrations was observed in infants receiving dexamethasone. Alanine, glutamine, citrulline, ornithine and cystine concentrations increased twofold or more. The 3MH:creatinine ratio was increased in the treated group. These metabolic effects were most likely due to an increase in protein catabolism.
Relation:	INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 36(5):1127-1136
Appears in Collections:	[School of Medicine] Journal articles

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