Rapid screening assay of congenital adrenal hyperplasia by measuring 17 alpha-hydroxyprogesterone with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry from dried blood spots

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Title:	Rapid screening assay of congenital adrenal hyperplasia by measuring 17 alpha-hydroxyprogesterone with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry from dried blood spots
Authors:	Lai, CC;Tsai, CH;Tsai, FJ;Wu, JY;Lin, WD;Lee, CC
Contributors:	附設醫院基因醫學部;China Med Coll Hosp, Dept Med Genet & Med Res, Taichung 404, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:45:41 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	Objective: To evaluate the association between endometriosis and the p53 polymorphism. Design: Prospective study. Setting: Department of gynecology and genetics in a medical center. Patient(s): Women with and without endometriosis. Intervention(s): Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140). Main Outcome Measure(s): Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated. Result(s): The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis. Conclusion(s): Endometriosis is associated with p53 polymorphism, p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis. (Fertil Steril(R) 2002;77:43-5. (C) 2002 by American Society for Reproductive Medicine.).
Relation:	JOURNAL OF CLINICAL LABORATORY ANALYSIS 16(1):20-25
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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