Novel CLCN1 mutations in Taiwanese patients with myotonia congenita

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29858

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/29858

题名:	Novel CLCN1 mutations in Taiwanese patients with myotonia congenita
作者:	Jou, SB;Chang, LI;Pan, HC;Chen, PR;Hsiao, KM
贡献者:	附設醫院神經醫學部;Chung Shan Med Univ, Dept Life Sci, Taichung 402, Taiwan;Chung Shan Med Univ, Dept Life Sci, Taichung, Taiwan;China Med Univ Hosp, Dept Neurol, Taichung, Taiwan;Chung Shan Med Univ, Instrument Ctr, Taichung, Taiwan
日期:	2004
上传时间:	2010-09-24 14:44:03 (UTC+8)
出版者:	DR DIETRICH STEINKOPFF VERLAG
摘要:	Huangbai (Phellodendron spec.) and Qianniuzi (Pharbitis spec.) are two traditional Chinese medical herbs used for anti-diarrheal and laxative agents, respectively. Ethanol and water extracts of these two herbs were prepared and effects of the extracts on ion transport of the rat intestinal epithelia were studied. For measuring changes of the short circuit current across the epithelia, the rat intestinal epithelia were mounted in the Ussing chamber and attached with voltage/current clamp. The intestinal epithelia were firstly activated by scrosal administration of 5 muM forskolin. As current raised and being stable, extracts of these herbs were added, respectively, and changes in the short circuit current were recorded. Ethanol extract of Huangbai attenuated the current increment; on the contrary, ethanol extract of Qianniuzi augmented the current increment additionally. Water extracts of the two herbs showed minor effects on the current in comparison to ethanol extracts. The results provide evidences to reveal the pharmacological mechanism of the two Chinese medical herbs on the intestinal tissue. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
關聯:	JOURNAL OF NEUROLOGY 251(6):666-670
显示于类别:	[台中附設醫院] 期刊論文

文件中的档案:

没有与此文件相关的档案.

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....