Novel CLCN1 mutations in Taiwanese patients with myotonia congenita

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Title:	Novel CLCN1 mutations in Taiwanese patients with myotonia congenita
Authors:	Jou, SB;Chang, LI;Pan, HC;Chen, PR;Hsiao, KM
Contributors:	附設醫院神經醫學部;Chung Shan Med Univ, Dept Life Sci, Taichung 402, Taiwan;Chung Shan Med Univ, Dept Life Sci, Taichung, Taiwan;China Med Univ Hosp, Dept Neurol, Taichung, Taiwan;Chung Shan Med Univ, Instrument Ctr, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:44:03 (UTC+8)
Publisher:	DR DIETRICH STEINKOPFF VERLAG
Abstract:	Huangbai (Phellodendron spec.) and Qianniuzi (Pharbitis spec.) are two traditional Chinese medical herbs used for anti-diarrheal and laxative agents, respectively. Ethanol and water extracts of these two herbs were prepared and effects of the extracts on ion transport of the rat intestinal epithelia were studied. For measuring changes of the short circuit current across the epithelia, the rat intestinal epithelia were mounted in the Ussing chamber and attached with voltage/current clamp. The intestinal epithelia were firstly activated by scrosal administration of 5 muM forskolin. As current raised and being stable, extracts of these herbs were added, respectively, and changes in the short circuit current were recorded. Ethanol extract of Huangbai attenuated the current increment; on the contrary, ethanol extract of Qianniuzi augmented the current increment additionally. Water extracts of the two herbs showed minor effects on the current in comparison to ethanol extracts. The results provide evidences to reveal the pharmacological mechanism of the two Chinese medical herbs on the intestinal tissue. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Relation:	JOURNAL OF NEUROLOGY 251(6):666-670
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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