中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/29845
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    题名: The three-item clock-drawing test: A simplified screening test for Alzheimer's disease
    作者: Lin, KN;Wang, PN;Chen, C;Chiu, YH;Kuo, CC;Chuang, YY;Liu, HC
    贡献者: 附設醫院神經部;Taipei Vet Gen Hosp, Neurol Inst, Taipei 112, Taiwan;Natl Yang Ming Univ, Sch Med, Dept Neurol, Taipei 112, Taiwan;China Med Coll Hosp, Dept Neurol, Taichung, Taiwan;Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA
    日期: 2003
    上传时间: 2010-09-24 14:43:45 (UTC+8)
    出版者: KARGER
    摘要: Baicalin, baicalcein, wogonoside and wogonin are flavone constituents of Scutellariae Radix with various beneficial biological activities. The purpose of this study was to investigate the urinary pharmacokinetics of these flavones after oral administration of Scutellariae Radix commercial powder. Ten healthy male volunteers received a dose of 5.2 g commercial powder (comparable to 9 g crude drug), respectively. The concentrations of baicalin, baicalein and wogonin in the commercial powder as well as their metabolites in urine were assayed by HPLC method. The glucuronides and sulfates of baicalein and wogonin in urine were hydrolyzed with beta-glucuronidase and sulfatase, respectively. Our results showed that the mean cumulated renal excretion of baicalein glucuronides and sulfates were 43.1 +/- 4.5 mumol (2.9% of dose) and 64.8 +/- 6.3 mumol (4.3% of dose), respectively, whereas wogonin glucuronides and sulfates were 21.6 +/- 2.0 mumol (5.9% of dose) and 20.7 +/- 1.7 mumol (5.7% of dose), respectively. The result indicated that the renal excretion of conjugated metabolites of wogonin (11.6% of dose) were higher than that of baicalein (7.2% of dose). The baicalein sulfates was predominant than the corresponding glucuronides, whereas wogonin sulfates was comparable to the corresponding glucuronides.
    關聯: EUROPEAN NEUROLOGY 49(1):53-58
    显示于类别:[台中附設醫院] 期刊論文

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