The three-item clock-drawing test: A simplified screening test for Alzheimer's disease

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Title:	The three-item clock-drawing test: A simplified screening test for Alzheimer's disease
Authors:	Lin, KN;Wang, PN;Chen, C;Chiu, YH;Kuo, CC;Chuang, YY;Liu, HC
Contributors:	附設醫院神經部;Taipei Vet Gen Hosp, Neurol Inst, Taipei 112, Taiwan;Natl Yang Ming Univ, Sch Med, Dept Neurol, Taipei 112, Taiwan;China Med Coll Hosp, Dept Neurol, Taichung, Taiwan;Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA
Date:	2003
Issue Date:	2010-09-24 14:43:45 (UTC+8)
Publisher:	KARGER
Abstract:	Baicalin, baicalcein, wogonoside and wogonin are flavone constituents of Scutellariae Radix with various beneficial biological activities. The purpose of this study was to investigate the urinary pharmacokinetics of these flavones after oral administration of Scutellariae Radix commercial powder. Ten healthy male volunteers received a dose of 5.2 g commercial powder (comparable to 9 g crude drug), respectively. The concentrations of baicalin, baicalein and wogonin in the commercial powder as well as their metabolites in urine were assayed by HPLC method. The glucuronides and sulfates of baicalein and wogonin in urine were hydrolyzed with beta-glucuronidase and sulfatase, respectively. Our results showed that the mean cumulated renal excretion of baicalein glucuronides and sulfates were 43.1 +/- 4.5 mumol (2.9% of dose) and 64.8 +/- 6.3 mumol (4.3% of dose), respectively, whereas wogonin glucuronides and sulfates were 21.6 +/- 2.0 mumol (5.9% of dose) and 20.7 +/- 1.7 mumol (5.7% of dose), respectively. The result indicated that the renal excretion of conjugated metabolites of wogonin (11.6% of dose) were higher than that of baicalein (7.2% of dose). The baicalein sulfates was predominant than the corresponding glucuronides, whereas wogonin sulfates was comparable to the corresponding glucuronides.
Relation:	EUROPEAN NEUROLOGY 49(1):53-58
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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