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http://ir.cmu.edu.tw/ir/handle/310903500/29683
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| 題名: | Differentiating recurrent or residual nasopharyngeal carcinomas from post-radiotherapy changes with 18-fluoro-2deoxyglucose positron emission tomography and thallium-201 single photon emission computed tomography in patients with indeterminate computed tomography findings |
| 作者: | Tsai, MH;Huang, WS;Tsai, JJP;Chen, YK;Changlai, SP;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung, Taiwan;China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan;China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan;Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Nucl Med, Taipei, Taiwan;Tri Serv Gen Hosp, Natl Def Med Ctr, PET Ctr, Taipei, Taiwan;Taichung Healthcare & Management Univ, Grad Inst Bioinformat, Taichung, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:40:23 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | The effects of Saikosaponin-A on human breast cancer cell lines (MDA-MB-231 and MCF-7) were investigated. Results demonstrated that Saikosaponin-A inhibited the proliferation or viability of the MDA-MB-231 and MCF-7 cells in a dose-dependent manner. Saikosaponin-A treatment of MDA-MB-231 for 3 hours and of MCF-7 cells for 2 hours, respectively caused an obvious increase in the sub-G I population of cell cycles. Apoptosis in MDA-MB-231 cells was independent of the P53/p21 pathway mechanism and was accompanied by an increased ratio of Bax to Bcl-2 and c-myc levels and activation of caspase-3. In contrast, apoptosis of MCF-7 cells may have been initiated by the Bcl-2 family of proteins and involved p53/p21 dependent pathway mechanism, and was accompanied by an increased level of cmyc protein. Both the apoptosis of MDA-MB-231 cells and MCF-7 cells showed a difference worthy of further research. |
| 關聯: | ANTICANCER RESEARCH 23(4):3513-3516 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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